10-4810
NU7441
Größe
£139.00
- SKU:
- 10-4810
- Zusätzliche Namen:
- Ku-57788
- Physischer Zustand:
- Solid
- Molekulargewicht:
- 413.49
- Reinheit:
- 98%
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- CAS Number:
- 503468-95-9
- Immunogen:
- Kinase
- Weitere Details:
- NU7441 is a potent (IC50 = 13 nM) and selective ATP-competitive inhibitor of DNA-dependent protein kinase (DNA-PK).1,2 It increased the toxicity of ionizing radiation and etoposide on SW620 human colon cancer lines via impeding DNA double-strand break repair.3 NU7441 also increased the radio/chemosensitivity of various other cancer cell lines.3-6 Reduces the frequency of NHEJ repair while enhancing the rate of HDR repair following CRISPR/Cas9-mediated gene editing.7
- Versandbedingungen:
- Ambient