10-4782
Crenolanib
Größe
£158.00
- SKU:
- 10-4782
- Zusätzliche Namen:
- CP-868,596
- Physischer Zustand:
- Solid
- Molekulargewicht:
- 443.55
- Reinheit:
- 97%
- Aufreinigung:
- HPLC Purified
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- CAS Number:
- 670220-88-9
- Immunogen:
- Kinase
- Weitere Details:
- Crenolanib is a potent inhibitor of PDGFR (Kd for A Alpha = 2.1 nM; B Beta = 3.2 nM) and FLT3 (Kd = 0.74 nM).1 Crenolanib is a type I inhibitor binding only to the active kinase conformation. It showed potent activity against imatinib-resistant PDGFRA Alpha mutations D842I, D842V, D842Y, DI842-843M, and deletion I8432 as well as FLT3/ITD and FLT3/D835 mutants3. Crenolanib acted synergistically with FLT3-CAR T-cells in a FLT3-ITD+ AML murine xenograft model.4
- Versandbedingungen:
- Ambient