10-4760
Palbociclib
Größe
£149.00
- SKU:
- 10-4760
- Zusätzliche Namen:
- PD-332991|PD0332991
- Physischer Zustand:
- Solid
- Molekulargewicht:
- 447.53
- Reinheit:
- 99%
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- CAS Number:
- 571190-30-2
- Immunogen:
- Kinase
- Weitere Details:
- Potent and selective inhibitor of Cdk4, IC50 = 11 nM and Cdk6, IC50 = 16 nM.1 Inhibits phosphorylation of Rb protein and cell cycle progression through G1 in primary 5T33MM cells and sensitized these cells to killing by a proteasome inhibitor (bortezomib) in mouse models.2 Induces autophagy and senescence in AGS gastric cancer cells.3 Clinically useful breast cancer agent.4 Cell cycle inhibitors boost tumor immunogenicity.5
- Versandbedingungen:
- Ambient