(R)-(+)Etomoxir Na

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£158.00

SKU:: 10-4731
Physischer Zustand:: Solid
Molekulargewicht:: 320.74
Reinheit:: 98%
Aufreinigung:: HPLC Purified
Lagerbedingungen:: -20[o]C
Hersteller:: Focus Biomolecules
CAS Number:: 828934-41-4
Immunogen:: Acyltransferase
Weitere Details:: Etomoxir (828934-41-4) is an irreversible inhibitor of mitochondrial carnitine palmitoyl transferase 1 (CPT1).1 It is widely used to study fatty acid oxidation. Etomoxir has been investigated as a therapeutic agent for heart disease2, diabetes3, and cancer4,5. Use of etomoxir in concentrations greater than 5 uM induces acute production of ROS with associated evidence of severe oxidative stress in proliferating T cells indicating a loss of specificity for CTP1 at these concentrations.6 200 uM etomoxir inhibited complex I of the electron transport chain.7