ML365

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£168.00

SKU:: 10-4658
Physischer Zustand:: Solid
Molekulargewicht:: 360.41
Reinheit:: >98%
Aufreinigung:: HPLC Purified
Lagerbedingungen:: -20[o]C
Hersteller:: Focus Biomolecules
CAS Number:: 947914-18-3
Immunogen:: Inflammasome|Ion channel
Weitere Details:: ML365 is a potent (IC50 = 16 nM) and selective (62-fold selective over TASK-3) blocker of the two-pore domain potassium channel K2P3.1 (TASK-1) .1 It also less potently (IC50 = 4.07 uM) blocks the K2P6.1 (TWIK-2) channel resulting in blocking the ATP-induced NLRP3 inflammasome.2 ML365 improved the efficacy of Levetiracetam in chronically epileptic rats.3 It suppressed the release of TNF-A Alpha, IL-6, and IL-1B Beta in an LPS-induced inflammatory model via regulation of NF-kB signaling.4