P505-15

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£173.00

SKU:: 10-4650
Zusätzliche Namen:: BIIB-057|PRT062607
Physischer Zustand:: Solid
Molekulargewicht:: 429.91
Reinheit:: >98%
Aufreinigung:: HPLC Purified
Lagerbedingungen:: -20[o]C
Hersteller:: Focus Biomolecules
CAS Number:: 1370261-97-4
Immunogen:: Kinase
Weitere Details:: P505-15 is a highly selective and potent (IC50 = 1-2 nM) inhibitor of spleen tyrosine kinase (Syk).1 It potently inhibited B cell antigen receptor-mediated B cell signaling/activation and basophil degranulation. It displayed anti-inflammatory activity in rodent models of rheumatoid arthritis. P505-15 displayed efficacy in vitro and in vivo in non-Hodgkin lymphoma and chronic lymphocytic leukemia models.2,3 It protected against toxin-induced hepatic fibrosis, associated hepatocellular injury, and hepatocarcinogenesis.4 P505-15 was also found to inhibit PINK1 (IC50 = 0.5-3 uM) in HeLa cells and dopaminergic neurons.5