10-4629
Azoramide
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£149.00
- SKU:
- 10-4629
- Physischer Zustand:
- Solid
- Molekulargewicht:
- 308.83
- Reinheit:
- 98%
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- CAS Number:
- 932986-18-0
- Immunogen:
- ER/Golgi|UPR (Unfolded Protein Response)
- Weitere Details:
- Azoramide is a modulator of the unfolded protein response (UPR).1 It improves endoplasmic reticulum (ER) protein folding and activates ER chaperone capacity to protect cells against ER stress. It displayed potent anti-diabetic activity in two mouse models by improving insulin sensitivity and pancreatic B Beta cell function. Azoramide increased SERCA expression leading to enhanced calcium retention in the ER indicating calcium homeostasis as a possible mechanism for its anti-diabetic acitivty.
- Versandbedingungen:
- Ambient