10-4628
SRT1720 HCl
Größe
£163.00
- SKU:
- 10-4628
- Zusätzliche Namen:
- SIRT 1933
- Physischer Zustand:
- Solid
- Molekulargewicht:
- 506.02
- Reinheit:
- 98%
- Aufreinigung:
- HPLC Purified
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- CAS Number:
- 1001645-58-4
- Immunogen:
- Protein deacetylase
- Weitere Details:
- SIRT1 activator (EC1.5 = 0.16 uM, max activation = 781%).1 It reduced glucose levels and hyperinsulinemia in DIO, Lepob/ob mice and Zucker fa/fa rats. SRT1720 enhanced endurance running and protected against diet-induced obesity and insulin resistance via enhancement of oxidative metabolism in skeletal muscle, liver, and brown adipose tissue.2 It induced mitochondrial biogenesis in oxidant-induced renal proximal tube cell injury.3 SRT1720 repressed circadian clock gene expression and decreased H3 K9/K14 acetylation in a time-specific manner.4 It attenuated angiotensin II-induced atherosclerosis by inhibiting the vascular inflammatory response.5
- Versandbedingungen:
- Ambient