10-4604
SHP099
Größe
£173.00
- SKU:
- 10-4604
- Physischer Zustand:
- Solid
- Molekulargewicht:
- 352.27
- Reinheit:
- 98%
- Aufreinigung:
- HPLC Purified
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- CAS Number:
- 1801747-42-1
- Immunogen:
- Phosphatase
- Weitere Details:
- SHP099 is a potent (IC50 = 71 nM) and selective allosteric inhibitor of SHP2. SHP2 is a non-receptor tyrosine phosphatase that regulates cell survival and proliferation through activating the RAS-ERK pathway. It also mediates programmed cell death 1 (PD-1) and T-lymphocyte attenuator (BTLA) immune checkpoint pathways. Treatment with SHP099, in combination with ceritinib, halts growth of ALK-inhibitor resistant non-small-cell lung cancer cells.3 Thus, reduction of SHP2 activity is a potential important cancer therapy target. It showed no activity against a panel of 21 other human phosphatases and 66 kinases.
- Versandbedingungen:
- Ambient