Fumarate hydratase-IN-1

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£168.00

SKU:: 10-4578
Physischer Zustand:: Solid
Molekulargewicht:: 446.55
Reinheit:: >98%
Aufreinigung:: HPLC Purified
Lagerbedingungen:: -20[o]C
Hersteller:: Focus Biomolecules
CAS Number:: 1644060-37-6
ABP:: No Import Docs
Weitere Details:: Fumarate hydratase-IN-1 is a pro-drug inhibitor of fumarate hydratase, an important enzyme in the tricarboxylic acid (TCA) cycle. This cell permeable compound is converted to the active carboxylic acid by intracellular esterases (Ki = 4.5 uM for free acid). The ethyl ester displayed cell-growth inhibitory activity against several cancer lines under nutrient (glucose) deprived conditions with an average IC50 = 2.2 uM.