NLG919

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£158.00

SKU:: 10-4564
Physischer Zustand:: Solid
Molekulargewicht:: 282.39
Lagerbedingungen:: -20[o]C
Hersteller:: Focus Biomolecules
CAS Number:: 1402836-58-1
Immunogen:: Tryptophan
Weitere Details:: NLG919 (1402836-58-1) is a potent IDO-pathway inhibitor (Ki = 7nM; EC50 = 75nM).1 It synergizes with chemo-radiation therapy to promote T cell dependent complement deposition in a murine model of glioblastoma.2 In combination with paclitaxel in a mouse B16-F10 melanoma model, NLG919 increased the percentage of CD3+, CD8+, and CD4+ T cells and secretion of IFN-G Gamma and interleukin-2 while decreasing the percentage of CD4+CD25+ regulatory T cells.3