10-4553
POB
Größe
£173.00
- SKU:
- 10-4553
- Physischer Zustand:
- Solid
- Molekulargewicht:
- 397.47
- Reinheit:
- 98%
- Aufreinigung:
- HPLC Purified
- Lagerbedingungen:
- RT
- Hersteller:
- Focus Biomolecules
- CAS Number:
- 946135-39-3
- Immunogen:
- Polyamine
- Weitere Details:
- Pyridoxal 5'-phosphate - dependent ornithine decarboxylase (ODC) is a key enzyme involved in polyamine synthesis and a potential cancer drug target. POB is a transition state-based, cell permeable pro-drug inhibitor of ODC. Intracellularly, POB is phosphorylated by pyridoxal kinase and the methyl ester hydrolyzed. This active inhibitor most likely binds apo-ODC resulting in greatly reduced ODC activity and inhibition of cellular proliferation. POB was able to inhibit proliferation in a wide variety of tumor cell lines: LN229 (IC50 = 50 uM), Jurkat, COS7, SW2 and both high and low-grade glioblastoma multiforme. More potent than DFMO.
- Versandbedingungen:
- Ambient