10-4517
Salubrinal
Größe
£153.00
- SKU:
- 10-4517
- Physischer Zustand:
- Solid
- Molekulargewicht:
- 479.81
- Reinheit:
- 98%
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- CAS Number:
- 405060-95-9
- Immunogen:
- Phosphatase|UPR (Unfolded Protein Response)
- Weitere Details:
- Endoplasmic reticulum (ER) stress inhibitor. Salubrinal is a selective inhibitor of cellular complexes that dephosphorylate eukaryotic initiation factor 2 subunit alpha (eIF2A Alpha).1 It has been found to interact with the anti-apoptotic protein Bcl-2 offering protection from the apoptotic and autophagic effects that result from loss of Bcl-2 function.2 Salubrinal blocked NFATc1 expression and osteoclast differentiation by RANKL via phosphorylation of eLF2A Alpha resulting in a decrease of global protein synthesis. It efficiently blocked osteoporosis in a mouse model treated with RANKL.3
- Versandbedingungen:
- Ambient