10-4511
Ruxolitinib
Größe
£163.00
- SKU:
- 10-4511
- Zusätzliche Namen:
- INCB 018424
- Physischer Zustand:
- Solid
- Molekulargewicht:
- 306.37
- Reinheit:
- 99%
- Aufreinigung:
- HPLC Purified
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- CAS Number:
- 941678-49-5
- Immunogen:
- Kinase
- Weitere Details:
- Potent and selective JAK1&2 inhibitor, IC50s=2.7, 4.5 and 322 nM forJAK1, JAK2 and JAK3 respectively.1 Blocks IL-6 signaling (IC50=281 nM) and proliferation of JAK2V617F+ Ba/F3 cells (IC50=127 nM).2 Inhibits the proinflammatory secretome of senescent cells.3 The JAK1 S646P mutant is highly sensitive to ruxolitinib.4 Clinically useful cancer chemotherapeutic.
- Versandbedingungen:
- Ambient