PF-06840003

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£158.00

SKU:: 10-4498
Zusätzliche Namen:: EOS200271
Physischer Zustand:: Solid
Molekulargewicht:: 232.21
Reinheit:: 98%
Lagerbedingungen:: -20[o]C
Hersteller:: Focus Biomolecules
CAS Number:: 198474-05-4
Immunogen:: Tryptophan
Weitere Details:: PF-06840003 (198474-05-4) is a potent (IC50 = 150 and 410 nM via two methods) and selective inhibitor of Indoleamine-2,3-dioxygenase (IDO1).1 In mice with syngeneic tumor grafts, it reduced intratumoral kynurenine levels by over 80%, inhibited tumor growth as monotherapy, and increased the efficacy of anti-PD-L1 therapy.2 PF-06840003 treatment combined with GM-CSF-secreting allogenic pancreatic tumor cell vaccine (GVAX) resulted in increased antitumor efficacy in a murine model of pancreatic ductal adenocarcinoma.3