Crisdesalazine

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£163.00

SKU:: 10-4416
Zusätzliche Namen:: AAD-2004
Physischer Zustand:: Solid
Molekulargewicht:: 325.29
Reinheit:: >98%
Aufreinigung:: HPLC Purified
Lagerbedingungen:: -20[o]C
Hersteller:: Focus Biomolecules
CAS Number:: 927685-43-6
Immunogen:: GPCR
Weitere Details:: Crisdesalazine is a potent inhibitor of microsomal prostaglandin E2 synthase-1 (IC50 = 230 nM).1 It also acted as a potent spin-trapping molecule and completely removed free radical at 50 nM. Crisdesalazine displayed efficacy in mouse models of ALS1 and Alzheimer's disease2. In a mouse model of spinal cord injury, it inhibited proliferation of astrocytes via hydrogen peroxide inhibition and promoted nerve regeneration.3 It also significantly alleviated clinical symptoms in a mouse model of multiple sclerosis by promoting the M1 to M2 phase transition in macrophages.4 Crisdesalazine in combination with cisplatin restored CD8+ T cell function and significantly improved efficacy compared to cisplatin monotherapy in an ovarian cancer model.5