10-4355
(R)-GNE-140
Größe
£177.00
- SKU:
- 10-4355
- Physischer Zustand:
- Solid
- Molekulargewicht:
- 499.04
- Reinheit:
- >98%
- Aufreinigung:
- HPLC Purified
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- CAS Number:
- 2003234-63-5
- Immunogen:
- Dehydrogenase (GAPDH, GPDH, IMPDH, PHGDH, LDH, DHODH, ALDH, GDH, IDH, UGDH, DPD, DHPDH, KGDH, PDH, and MDH)
- Weitere Details:
- (R)-GNE-140 is a potent (IC50's: LDHA = 3 nM, LDHB = 5 nM, LDHC = 5 nM) pan-lactate dehydrogenase inhibitor.1 It significantly decreased lactate levels in vivo, although the effects were transient. GNE-140 suppressed lactic acid production, severely stunted glucose utilization, and impeded the anaerobic glycolytic pathway in MDA-MB-231 triple negative breast cancer cells.2
- Versandbedingungen:
- Ambient