10-4241
WC522
Größe
£177.00
- SKU:
- 10-4241
- Physischer Zustand:
- Amber viscous oil
- Molekulargewicht:
- 380.53
- Reinheit:
- >98%
- Aufreinigung:
- HPLC Purified
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- Immunogen:
- Transcription factor
- Weitere Details:
- WC522 blocks the cholesterol-dishevelled interaction leading to inhibition of B Beta-catenin signaling. It specifically inhibits the Dvl2-PDZ-cholesterol interaction (IC50 = 40 nM) leading to suppression of both Wnt-independent and Wnt-stimulated B Beta-catenin signaling (IC50 = 150 nM). WC522 inhibits cell proliferation in APC-truncated colorectal carcinoma cells and colorectal carcinoma HCT15 xenografts in mice.
- Versandbedingungen:
- Ambient