10-4124
Alisertib
Größe
£163.00
- SKU:
- 10-4124
- Zusätzliche Namen:
- MLN8237
- Physischer Zustand:
- Solid
- Molekulargewicht:
- 518.92
- Reinheit:
- 98%
- Aufreinigung:
- HPLC Purified
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- CAS Number:
- 1028486-01-2
- Immunogen:
- Kinase
- Weitere Details:
- Alisertib (MLN8237) is a highly selective and potent (IC50 = 1 nM) cell permeable inhibitor of Aurora A with off-target binding at GABAA (IC50 = 490 nM).1 It disrupts the Aurora A-Myc complex leading to Myc degradation2 in Myc amplified neuroblastomas3 and p53-mutant human hepatocellular carcinoma cell4. Alisertib has been found to induce apoptosis and autophagy in breast cancer5 and melanoma6 cells via suppression of activation of the p38 MAPK pathway.
- Versandbedingungen:
- Ambient