AZD7648

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£173.00

SKU:: 10-4108
Physischer Zustand:: Solid
Molekulargewicht:: 380.41
Reinheit:: >98%
Aufreinigung:: HPLC Purified
Lagerbedingungen:: -20[o]C
Hersteller:: Focus Biomolecules
CAS Number:: 2230820-11-6
Immunogen:: DNA|Kinase
Weitere Details:: AZD7648 is a very potent and selective (against 397 kinases) DNA-PK inhibitor (pIC50 = 9.2; cellular pIC50 = 7.0).1 It is a sensitizer of radiation- and doxorubicin-induced DNA damage and sustained tumor regression in xenograft and patient-derived xenograft models.2 AZD7648 significantly enhances precise CRISPR/Cas9 gene editing alone3,4,5 or in combined treatment with a DNA polymerase theta inhibitor (2iHDR cocktail)5.