10-4086
Serodolin
Größe
£177.00
- SKU:
- 10-4086
- Physischer Zustand:
- Solid
- Molekulargewicht:
- 382.47
- Reinheit:
- >98%
- Aufreinigung:
- HPLC Purified
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- CAS Number:
- 1814929-81-1
- Immunogen:
- GPCR|Serotonin
- Weitere Details:
- Serodolin is a potent dual antagonist of the serotonin receptors 5-HT7 (Ki = 6.2 nM; IC50 = 5.7 nM cAMP response) and 5-HT2A (Ki = 19 nM; IC50 = 110 nM IP1 response) with significant selectivity over 5-HT1A and 5-HT6.1 Serodolin has recently been found to act as a B Beta-arrestin-biased inverse agonist on Gs signaling while inducing ERK activation requiring c-SRS activation, a unique pharmacological profile among 5-HT7 ligands.2 It decreased hyperalgesia and pain sensation in response to inflammatory, thermal, and mechanical stimulation in a mouse model demonstrating the therapeutic potential of a B Beta-arrestin-biased ligand for pain relief. Blood-brain barrier permeable.
- Versandbedingungen:
- Ambient