SIC5-6

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£149.00

SKU:: 10-4075
Physischer Zustand:: Solid
Molekulargewicht:: 581.47
Reinheit:: 97%
Aufreinigung:: HPLC Purified
Lagerbedingungen:: -20[o]C
Hersteller:: Focus Biomolecules
CAS Number:: 2410846-16-9
Immunogen:: Cytoskeleton|Protease
Weitere Details:: Separase is a cysteine protease that triggers chromosome segregation during mitosis and is highly overexpressed in many cancers. SIC5-6 is an inhibitor of separase with no inhibition of the related protease caspase-1 in vitro. HeLa cells with dysregulated separase activity showed severe chromosome segregation defects on treatment with 30 uM SIC5-6 indicating a potential attractive new chemotherapeutic target.