A-438079 HCl

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£158.00

SKU:: 10-4063
Physischer Zustand:: Solid
Molekulargewicht:: 342.61
Reinheit:: 98%
Aufreinigung:: HPLC Purified
Lagerbedingungen:: -20[o]C
Hersteller:: Focus Biomolecules
CAS Number:: 899431-18-6
Immunogen:: Ion channel
Weitere Details:: A-438079 (899431-18-6) is a competitive P2X7 receptor antagonist (pIC50 = 6.9).1 Displayed antinociceptive effects in a rat model of neuropathic pain.2 A-438079 prevented the LPS-induced release of IL-1B Beta and attenuated LPS-induced (via intrathecal lumbar injection) mechanical hyperalgesia in rat hindpaws.3 It prevented mechanical hyperalgesia following peripheral nerve injury.4 A-438079 protected against cerebral ischemia/reperfusion injury in a rat model via reduction of the neuroinflammatory response.5