10-4056
AZD3965
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- SKU:
- 10-4056
- Physischer Zustand:
- Solid
- Molekulargewicht:
- 515.51
- Reinheit:
- 98%
- Aufreinigung:
- HPLC Purified
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- CAS Number:
- 1448671-31-5
- Weitere Details:
- AZD3965 is a potent inhibitor (Ki's: 1.6 - 3.2 nM) of monocarboxylate transporter 1 (MCT1) with approximately 6-fold selectivity over MCT2.1 Active in multiple cancer models as monotherapy or in combination with other chemotherapeutics.2 AZD3965 improved CAR-T cell therapy against B-cell malignancies.3 It inhibited lipid biosynthesis and increased tumor infiltration of dendritic and natural killer cells.4 Combination therapy with immune checkpoint blockade suppressed lactate-mediated immunosuppression in the tumor microenvironment.5
- Versandbedingungen:
- Ambient