10-4043
GSK484 hydrochloride
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£187.00
- SKU:
- 10-4043
- Physischer Zustand:
- Solid
- Molekulargewicht:
- 510.04
- Reinheit:
- >98%
- Aufreinigung:
- HPLC Purified
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- CAS Number:
- 1652591-81-5
- Weitere Details:
- GSK484 is a potent (IC50 = 50 nM) and selective inhibitor of protein arginine deiminase (PAD4).1 It blocks neutrophil extracellular trap formation in human neutrophils.1,2 GSK484 abrogates thrombus formation on heparin-induced thrombocytopenia/thrombosis.3 It protected against reperfusion injury in both stroke4 and cardiac5 models. GSK484 attenuated tumor cell stemness in esophageal squamous cell carcinoma.6 It prevented surgery-induced tumor recurrence via inhibition of neutrophil extracellular trap-induced reprogramming of cancer cell metabolism.7
- Versandbedingungen:
- Ambient