iJMJD6

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£173.00

SKU:: 10-4039
Zusätzliche Namen:: WL12
Physischer Zustand:: Solid
Molekulargewicht:: 277.28
Reinheit:: >98%
Lagerbedingungen:: -20[o]C
Hersteller:: Focus Biomolecules
CAS Number:: 899548-78-8
Immunogen:: Protein demethylase
Weitere Details:: Inhibitor of the arginine demethylase JMJD6 (IC50 = 220 nM) with selectivity over other JmjC domain-containing proteins.1 Exhibited antiproliferative effects in HeLa (EC50 = 1.49 uM), SMCC7721 (EC50 = 9.37 uM), and MCF7 (EC50 = 9.53 uM) cells.2 Displayed no cytotoxicity towards normal cervical, liver, and breast epithelial cells. iJMJD6 significantly suppressed tumor growth in a HeLa, SMCC7721, MCF7, MDA-MB-231, U87, and HCT116 mouse xenograft models.2