10-4038
iBAP-II
Größe
£182.00
- SKU:
- 10-4038
- Physischer Zustand:
- Solid
- Molekulargewicht:
- 308.33
- Reinheit:
- >98%
- Aufreinigung:
- HPLC Purified
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- CAS Number:
- 1013813-81-4
- ABP:
- No Import Docs
- Immunogen:
- DUB (Deubiquitinating enzyme)
- Weitere Details:
- Inhibitor of the H2AK119 deubiquitinase BAP1 (IC50 = 0.092 ug/ml). It is selective for BAP1 over UCHL5, USP5,7,8, TNFAIP3-catalytic domain, USP2-catalytic domain, Otubain-1, and Ataxin3. iBAP-II disrupted the BAP1/ASXL3/BRD4 axis via induction of protein degradation of the ASXL3 scaffold protein in the small cell lung cancer lines NCI-H1963, NCI-H748, and NCI-H1882. It also suppressed expression of the master transcription factor ASCL1 in NCI-H1963 small cell lung cancer cells. iBAP-II significantly delayed disease progression in a small cell lung cancer xenograft mouse model.
- Versandbedingungen:
- Ambient