10-4006
Grapiprant
Größe
£177.00
- SKU:
- 10-4006
- Zusätzliche Namen:
- ARY-007|CJ-023,423
- Physischer Zustand:
- Solid
- Molekulargewicht:
- 491.61
- Reinheit:
- 98%
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- CAS Number:
- 415903-37-6
- Immunogen:
- GPCR
- Weitere Details:
- Grapiprant is a potent (Ki = 13 nM for human and 20 nM for rat) and selective prostaglandin EP4 receptor antagonist.1 It produces antihyperalgesic effects in animal models of pain, and has significant anti-inflammatory effects in a rat model of adjuvant-induced arthritis.2 EP4 receptors have been shown to be involved in PGE2 stimulation of Th1 differentiation and Th17 expansion revealing a potential role for PGE2 receptors in immunosuppression.3,4 Grapiprant/Pembrolizumab combination is in clinical trials for advanced or metastatic NSCLC adenocarcinoma.5
- Versandbedingungen:
- Ambient