10-3976
RMC-6236
Größe
£144.00
- SKU:
- 10-3976
- Zusätzliche Namen:
- Daraxonrasib
- Physischer Zustand:
- Solid
- Molekulargewicht:
- 811.06
- Reinheit:
- >98%
- Aufreinigung:
- HPLC Purified
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- CAS Number:
- 2765081-21-6
- ABP:
- No Import Docs
- Immunogen:
- GTPase|Molecular glue
- Weitere Details:
- RMC-6236 is broad spectrum inhibitor of both mutant and wild-type KRAS, NRAS, and HRAS variants.1,2 It binds with high affinity to cyclophilin A (KD = 55 nM) creating a binary complex that has high affinity for the active state of KRAS (KD = 131 nM for G12V, 364 nM for G12D and 154 nM for wild type). Active in in vivo xenograft models of NSCLC, PDAC, colorectal cancer, gastric carcinoma, and ovarian adenocarcinoma.2
- Versandbedingungen:
- Ambient