10-3969
WX-02-23
Größe
£187.00
- SKU:
- 10-3969
- Zusätzliche Namen:
- (1R,3S)-2-Acryloyl-1-(benzo[d][1,3]dioxol-5-yl)-N-morpholino-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxamide
- Physischer Zustand:
- Solid
- Molekulargewicht:
- 459.5
- Reinheit:
- >98%
- Aufreinigung:
- HPLC Purified
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- CAS Number:
- 2929223-35-6
- ABP:
- No Import Docs
- Immunogen:
- RNA|Transcription factor
- Weitere Details:
- WX-02-23 is a spliceosome modulator. It binds to the spliceosome factor SF3B1 stabilizing a spliceosome state with enhanced binding to DDX42. WX-02-23 displayed anti-proliferative effects in Panc 05.04 and Panc 04.03 cells.1 WX-02-23 also modulates the pioneer transcription factor FOXA1 via covalent binding to Cysteine 258 in a DNA-dependent manner (EC50 = 2 uM FOXA1; 12 uM FOXA1-FKHD). It alters activity via relaxation of FOXA1s DNA-binding motif changing chromatin accessibility.2
- Versandbedingungen:
- Ambient