10-3963
PT-179
Größe
£168.00
- SKU:
- 10-3963
- Physischer Zustand:
- Solid
- Molekulargewicht:
- 343.34
- Reinheit:
- >98%
- Aufreinigung:
- HPLC Purified
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- CAS Number:
- 2924858-25-1
- Immunogen:
- Molecular glue|Ubiquitin ligase
- Weitere Details:
- PT-179 is an orthogonal thalidomide analog that binds cereblon (CRBN: KD = 587 nM; pomalidomide KD = 500 nM) with greatly reduced off-target activity compared to pomalidomide. Pomalidomide induced differential expression of 1426 genes in MM.1S multiple myeloma cells compared to only 3 for PT-179. PT-179 is an interesting new tool for exploring CRBN-based therapeutics.
- Versandbedingungen:
- Ambient