10-3954
RMC-7977
Größe
£177.00
- SKU:
- 10-3954
- Physischer Zustand:
- Solid
- Molekulargewicht:
- 865.11
- Reinheit:
- >98%
- Aufreinigung:
- HPLC Purified
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- CAS Number:
- 2765082-12-8
- Immunogen:
- GTPase|Molecular glue
- Weitere Details:
- RMC-7977 is broad spectrum inhibitor of both mutant and wild-type KRAS, NRAS, and HRAS variants.1 It binds with high affinity to cyclophilin A (KD = 195 nM) creating a binary complex that has high affinity for the active state of KRAS (KD = 85 nM for G12V). Active in in vivo xenograft models of NSCLC, CRC, and PDAC.1,2,3 RMC-7977 was able to overcome resistance to the KRASG12D selective inhibitor MRTX1133.1
- Versandbedingungen:
- Ambient