MAC-545496

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£158.00

SKU:: 10-3951
Physischer Zustand:: Solid
Molekulargewicht:: 419.88
Reinheit:: 98%
Lagerbedingungen:: -20[o]C
Hersteller:: Focus Biomolecules
CAS Number:: 838810-96-1
Weitere Details:: Inhibitor of glycopeptide-resistance-associated protein R (GraR, also known as ApsR). GraR and its regulatory system are important for virulence of S. aureus. MAC-545496 is able to reverse B Beta-lactam resistance in S. aureus in a G. Mellonella larvae model. 0.06 ug/mL MAC-545496 lowered the minimum inhibitory concentration (MIC) for oxacillin against S. aureus below the CLSI clinical breakpoint. It lowered the B Beta-lactam MIC from 512 to 8 ug/mL against S. aureus USA300.