ML382

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£182.00

SKU:: 10-3937
Zusätzliche Namen:: 2-(Cyclopropanesulfonamido)-N-(2-ethoxyphenyl)benzamide|VU0485891
Physischer Zustand:: Solid
Molekulargewicht:: 360.43
Reinheit:: 99%
Aufreinigung:: HPLC Purified
Lagerbedingungen:: -20[o]C
Hersteller:: Focus Biomolecules
CAS Number:: 1646499-97-9
Immunogen:: GPCR
Weitere Details:: ML382 is a potent (EC50 = 190 nM in the presence of the endogenous peptide MRGX1 agonist BAM8-22) and selective positive allosteric modulator of the Mas-related G protein-coupled receptor X1 (MRGX1 or MRGPRX1), a receptor whose expression is limited to subsets of small-diameter sensory neurons in dorsal root ganglia and trigeminal neurons.1 ML382 significantly enhanced the antihyperalgesic effects of exogenously added BAM8-22 and in mouse models of persistent pain without exogenous BAM8-22, suggesting enhanced pain inhibition from a sufficient supply of endogenous MRGPRX1 ligands and a potential new pain therapeutic.2