10-3933
SJ6986
Größe
£153.00
- SKU:
- 10-3933
- Physischer Zustand:
- Solid
- Molekulargewicht:
- 433.34
- Reinheit:
- 98%
- Aufreinigung:
- HPLC Purified
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- CAS Number:
- 2765625-93-0
- Immunogen:
- GTPase|Molecular glue
- Weitere Details:
- SJ6986 is a potent (IC50 = 15 nM for Cereblon; EC50 = 1.5 nM for MV4-11 AML cells), selective, and orally bioavailable molecular glue degrader of the small GTPases G1 to S phase transition 1/2 (GSPT1/2).1 It displayed selectivity for GPST1/2 over 9000 other proteins including the classic cereblon substrates IKZF1 (Ikaros) and IZKF3 (Aiolos). SJ6986 displayed efficacy against acute lymphoblastic leukemia cell lines and xenografts.2
- Versandbedingungen:
- Ambient