PY-60

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£173.00

SKU:: 10-3924
Physischer Zustand:: Solid
Molekulargewicht:: 313.38
Reinheit:: >98%
Aufreinigung:: HPLC Purified
Lagerbedingungen:: -20[o]C
Hersteller:: Focus Biomolecules
CAS Number:: 2765218-56-0
Immunogen:: Transcription factor
Weitere Details:: PY-60 (2765218-56-0) activates YAP transcriptional activity (EC50 = 1.6 uM) via delocalization of annexin A2 (ANXA2) from cell membranes leading to Hippo inactivation, a key controller of YAP.1 It was able to induce serum-free expansion of MCF10A cells and epidermal keratinocytes and their precursors ex vivo and in adult mice. PY-60 promoted regenerative repair of cutaneous wounds in pig and human models by enabling a pro-proliferative transcriptional program in keratinocytes and dermal cells that accelerated re-epithelization and regranulation of the wound bed.2