10-3902
Lipofermata
Größe
£163.00
- SKU:
- 10-3902
- Zusätzliche Namen:
- CB16.2
- Physischer Zustand:
- Solid
- Molekulargewicht:
- 360.23
- Reinheit:
- >98%
- Aufreinigung:
- HPLC Purified
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- CAS Number:
- 297180-15-5
- ABP:
- No Import Docs
- Weitere Details:
- Lipofermata is an inhibitor of fatty acid transport protein 2 (FATP2; IC50 = 4.84 uM).1 It does not inhibit glucose transport or the activity of long chain acyl-CoA synthetase. It prevented palmitate-mediated oxidative stress, induction of BiP and CHOP, and cell death in a dose-dependent manner in hsHepG2 and mINS-1E cells suggesting utility in preventing fatty acid-mediated cell death pathways and lipotoxic disease.2 Inhibition was specific for long and very long chain fatty acids but not medium (C6-C10) acids. Lipofermata abrogates lipid transport into melanoma cells and reduces melanoma growth and invasion.3
- Versandbedingungen:
- Ambient