10-3800
DJ001
Größe
£168.00
- SKU:
- 10-3800
- Physischer Zustand:
- Solid
- Molekulargewicht:
- 268.27
- Reinheit:
- 98%
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- CAS Number:
- 2161305-12-8
- Immunogen:
- Phosphatase
- Weitere Details:
- DJ001 (2161306-12-8) is a potent and specific inhibitor of receptor type protein tyrosine phosphatase-sigma (PTP) IC50=1.54 M and >10 M for 20 other phosphatases.1 Promotes hematopoietic stem cell regeneration in vivo. In mice treated with 5-fluorouricil or irradiated, DJ001 promoted HSC regeneration accelerated hematologic recovery and improved survival. The mode of inhibition of PTP is via non-competitive allosteric binding. Suppression of radiation-induced HSC apoptosis occurs via activation of Rho GTPase, Rac1 and induction of BCL-XL. Treatment of irradiated human HSCs with DJ001 promotes the regeneration of human HSCs capable of multilineage in vivo repopulation.1
- Versandbedingungen:
- Ambient