10-3743
Tafamidis
Größe
£158.00
- SKU:
- 10-3743
- Zusätzliche Namen:
- PF-06291826
- Physischer Zustand:
- Solid
- Molekulargewicht:
- 308.12
- Reinheit:
- 98%
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- CAS Number:
- 594839-88-0
- Immunogen:
- UPR (Unfolded Protein Response)
- Weitere Details:
- A potent and selective transthyretin (TTR) kinetic stabilizer. It binds selectively and with negative cooperativity to the two normally unoccupied thyroxine binding sites of the TTR tetramer (Kd = ~2 and ~200 nM)1. Stabilizes wild-type and mutant TTR under varying conditions in vitro (EC50=2.7-3.2 M).1 Clinically useful for the treatment of familial amyloid polyneuropathy2,3 and TTR-related cardiomyopathy4.
- Versandbedingungen:
- Ambient