10-3658
Neratinib
Größe
£149.00
- SKU:
- 10-3658
- Zusätzliche Namen:
- HKI-272
- Physischer Zustand:
- Solid
- Molekulargewicht:
- 557.05
- Reinheit:
- >98%
- Aufreinigung:
- HPLC Purified
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- CAS Number:
- 698387-09-6
- Immunogen:
- Kinase
- Weitere Details:
- Neratinib is a potent, irreversible inhibitor of HER2/ErbB2 receptor tyrosine kinase and EGFR kinase (IC50's= 59 nM and 92 nM, respectively). It suppresses receptor autophosphorylation and proliferation, blocks cell-cycle progression and inhibits HER2 signaling in of EGFR-dependent cancer cells and tumor xenograft models.1 Neratinib inhibits proliferation of gefitinib-resistant non-small cell lung cancer cells expressing mutant EGFR.2 Synergizes with dasatinib in HER2-positive cancer cells and xenografts.3 It's been shown to also inhibit MST1 (IC50 = 37.7 nM).4
- Versandbedingungen:
- Ambient