10-3556
Gramicidin A
Größe
£134.00
- SKU:
- 10-3556
- Zusätzliche Namen:
- Peptide fermentation product isolated from B brevis
- Physischer Zustand:
- Solid
- Molekulargewicht:
- 1882.29
- Reinheit:
- >95%
- Aufreinigung:
- HPLC Purified
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- CAS Number:
- 11029-61-1
- Immunogen:
- Antibiotic|Ionophore|RNA
- Weitere Details:
- Gramicidin A (11029-61-1) is a hydrophilic non-ribosomal peptide ionophore that forms channels in membranes which are monovalent cation-permeable.1,2 Disruption of cellular ionic homeostasis is the basis for its antibiotic activity.3 It is also cytotoxic to a variety of cancer cell lines4 and tumor xenografts5. Gramicidin A was shown to stimulate melanoma differentiation-associated protein 5 (MDA5)-mediated IFN signaling by enhancing its oligomerization onto RNA and thus represents a new tool to manipulate MDA5 activity.6
- Versandbedingungen:
- Ambient