B02

Größe

£139.00

SKU:: 10-3425
Physischer Zustand:: Solid
Molekulargewicht:: 339.4
Reinheit:: >98%
Aufreinigung:: HPLC Purified
Lagerbedingungen:: -20[o]C
Hersteller:: Focus Biomolecules
CAS Number:: 1290541-46-6
Immunogen:: DNA
Weitere Details:: RAD51 is a key protein involved in homologous recombination that plays a critical role in the repair of DNA double-strand breaks (DSB) and interstrand cross-links (ICL).1 B02 (1290541-46-6) was identified in a high-throughput screen using a DNA strand exchange assay and was found to specifically inhibit human RAD51 (IC50=27.4 uM) but not its E. coli homolog (RecA)1. It sensitizes multiple myeloma cells to doxorubicin2 and potentiates breast cancer cell killing by therapeutic agents in mouse models3. B02 induces a heat-shock protein mediated cellular response that positively regulates the conversion of rcDNA to cccDNA via the authentic intracellular amplification pathway in human hepatoma cells.4