10-3385
RITA
Größe
£168.00
- SKU:
- 10-3385
- Zusätzliche Namen:
- NSC 652287
- Physischer Zustand:
- Solid
- Molekulargewicht:
- 292.37
- Reinheit:
- 98%
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- CAS Number:
- 213261-59-7
- Immunogen:
- Ribosome|Transcription factor
- Weitere Details:
- RITA (reactivation of p53 and induction of tumor cell apoptosis) binds to p53 (Kd = 1.5 nM), changing its conformation, preventing it from binding to HDM2 (human ortholog of MDM2, Mouse Double-Minute clone 2), and targeting it for proteasomal degradation.1 It also weakly (computed Kd = 22 uM) binds HDM2 in the cleft that contacts the p53 transactivation domain.2 Its restoration of mutant p53 function depends on eIF2A Alpha phosphorylation, and it induces apoptosis via p53-dependent and -independent (JNK/SAPK/p38; protein translation) pathways.3-5 Induces senescence in head and neck cancer cells.6
- Versandbedingungen:
- Ambient