10-3326
Koningic acid
Größe
£197.00
- SKU:
- 10-3326
- Zusätzliche Namen:
- Avocettin|BRN5091359|Heptelidic acid
- Physischer Zustand:
- Solid
- Molekulargewicht:
- 280.32
- Reinheit:
- 95%
- Aufreinigung:
- HPLC Purified
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- CAS Number:
- 74310-84-2
- ABP:
- No Import Docs
- Immunogen:
- Dehydrogenase (GAPDH, GPDH, IMPDH, PHGDH, LDH, DHODH, ALDH, GDH, IDH, UGDH, DPD, DHPDH, KGDH, PDH, and MDH)
- Weitere Details:
- Koningic acid (KA) is a potent and selective inhibitor of glyceraldehyde-3-phosphate dehydrogenase (GAPDH).1 Inhibition is irreversible and proceeds via nucleophilic attack of an active site cysteine on the epoxide moiety2, Ki = 1.1 uM for rabbit muscle GAPDH3. KA can selectively kill high-glycolytic cancer cells via glucose dependent ATP depletion.4 Has been used in a predictive model for selective targeting of the Warburg effect, the most prominent hallmark of cancer cell metabolism.5
- Versandbedingungen:
- Ambient