10-3049
BMS-833923
Größe
£149.00
- SKU:
- 10-3049
- Zusätzliche Namen:
- XL-139
- Physischer Zustand:
- Solid
- Molekulargewicht:
- 473.58
- Reinheit:
- >98%
- Aufreinigung:
- HPLC Purified
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- CAS Number:
- 1059734-66-5
- Immunogen:
- GPCR
- Weitere Details:
- BMS-833923 (1059734-66-5) is a smoothened (SMO) antagonist. It decreased cell proliferation and induced apoptosis (EC50=10 mM) via the intrinsic pathway in esophageal adenocarcinoma cell lines.1 Ameloblastoma cells with an activating SMO-L412F mutation were insensitive to vismodegib (another SMO antagonist) but BMS-833923 significantly reduced downstream Hedgehog signaling and tumor cell viability.2 In developmental studies BMS-833923 has been characterized as a uniquely effective SMO inhibitor when it was used to show that Sonic hedgehog is functionally dedicated to ray branching during fin regeneration in zebrafish.3 Orally active.
- Versandbedingungen:
- Ambient