10-3033
Homoharringtonine
Größe
£149.00
- SKU:
- 10-3033
- Zusätzliche Namen:
- HHT|NSC141633|Omacetaxine mepesuccinate
- Physischer Zustand:
- Pale yellow to off-white solid
- Molekulargewicht:
- 545.63
- Reinheit:
- 95%
- Aufreinigung:
- HPLC Purified
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- CAS Number:
- 26833-87-4
- Immunogen:
- Antibiotic|DNA|Ribosome
- Weitere Details:
- A plant alkaloid, originally isolated from the Hainan plum yew, that binds to the large ribosomal subunit A-site, competing with aminoacyl-tRNA amino acid side chains, thereby inhibiting the initial elongation step of protein synthesis.1 It also binds to transcription factors NKRF (NF-K KappaB repressing factor) and SP1, down-regulating the Myc pathway.2,3 Dramatically decreases global DNA 5-hydroxymethylcytosine levels via the SP1/TET1 axis.3 Induces apoptosis in tyrosine kinase inhibitor-resistant NSCLC cells4, and is a clinically useful agent for CML and AML5.
- Versandbedingungen:
- Ambient