10-2990
MCC950
Größe
£154.00
- SKU:
- 10-2990
- Zusätzliche Namen:
- CP-456773 sodium salt|CRID3
- Physischer Zustand:
- Solid
- Molekulargewicht:
- 426.46
- Reinheit:
- 98%
- Aufreinigung:
- HPLC Purified
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- CAS Number:
- 210826-40-7
- Immunogen:
- Inflammasome
- Weitere Details:
- MCC950 was originally found to act as a cytokine release inhibitory drug (CRID), arresting activated monocytes and preventing activation of caspase-11. Discovered to be a novel inhibitor of the NLRP3 and AIM2 inflammasomes2. Blocks canonical and noncanonical NLRP3 activation at nanomolar concentrations3. Inhibits interleukin 1B Beta (IL-1B Beta) secretion in vivo and attenuates the severity of experimental autoimmune encephalomyelitis (an MS disease model)3. Disrupts the interaction between AIM2 and ASC in a reconstituted cell-free inflammasome4. A valuable new tool for exploring the pathophysiology of NLRP3.
- Versandbedingungen:
- Ambient