10-2979
PAC-1
Größe
£129.00
- SKU:
- 10-2979
- Physischer Zustand:
- Solid
- Molekulargewicht:
- 392.49
- Reinheit:
- 98%
- Aufreinigung:
- HPLC Purified
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- CAS Number:
- 315183-21-2
- Immunogen:
- Chelator|Protease
- Weitere Details:
- PAC-1 is a procaspase-activating compound, directly activating procaspase-3, producing caspase-3, EC50=0.22 uM.1 It is less potent at activating procaspase-7, EC50=4.5 uM. It induces apoptosis in a variety of cancer cell lines. The mechanism of activation involves sequestering inhibitory zinc ions thus allowing procaspase-3 to autoactivate.2 Sensitizes cancer cells to various chemotherapeutic agents.3
- Versandbedingungen:
- Ambient