10-2860
Kifunensine
Größe
£164.00
- SKU:
- 10-2860
- Zusätzliche Namen:
- FR-900494
- Physischer Zustand:
- Solid
- Molekulargewicht:
- 232.19
- Reinheit:
- 98%
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- CAS Number:
- 109944-15-2
- Immunogen:
- Glycosylation
- Weitere Details:
- Historically isolated from Kitasatosporia kifunensee.1 Inhibitor of class I A Alpha-mannosidases which inhibit glycoprotein processing. Inhibits human endoplasmic reticulum A Alpha-1,2-mannosidase I and Golgi Class I mannosidases IA, IB and IC with Ki values of 130 and 23 nM respectively.2 Inhibition of endoplasmic reticulum A Alpha-mannosidase I activity rescues the human A Alpha-sarcoglycan R77C mutation suggesting a new pharmacological approach for limb girdle muscular dystrophy type 2D patients carrying mutations that impair A Alpha-sarcoglycan trafficking.3 Improves maturation of misfolded proteins.4
- Versandbedingungen:
- Ambient