SB-225002

Größe

£158.00

SKU:: 10-2850
Physischer Zustand:: Solid
Molekulargewicht:: 352.14
Reinheit:: 98%
Aufreinigung:: HPLC Purified
Lagerbedingungen:: -20[o]C
Hersteller:: Focus Biomolecules
CAS Number:: 182498-32-4
Immunogen:: GPCR
Weitere Details:: Potent and selective CXCR2 receptor antagonist (IC50 = 22 nM). Displays >150-fold selectivity over CXCR1 receptors.1 Induces apoptosis in both wild-type and p53-deficient ovarian cancer cells (OVCA) via p53 activation and by inducing mitotic catastrophe.2 Blocks IL-8-mediated cellular effects such as oxidative stress-induced cellular senescence3 and neutrophil chemotaxis1. Inhibits HIV replication in lymphocytes and macrophages.4 Inhibits endothelial activation and leukocyte recruitment to cerebral microvessels during neuroinflammation.5